{"id":4112,"date":"2023-05-25T20:20:05","date_gmt":"2023-05-25T20:20:05","guid":{"rendered":"http:\/\/www.geneethic.com.tr\/?page_id=4112"},"modified":"2024-11-12T12:02:12","modified_gmt":"2024-11-12T12:02:12","slug":"untargeted-metabolomics","status":"publish","type":"page","link":"https:\/\/www.geneethic.com.tr\/?page_id=4112","title":{"rendered":"Untargeted Metabolomics"},"content":{"rendered":"[vc_row et_full_width=”true” et_row_padding=”true” css=”.vc_custom_1579113527778{padding-top: 120px !important;padding-bottom: 60px !important;background-color: #f6f6f6 !important;}”][vc_column css=”.vc_custom_1684760689814{background-color: #f6f6f6 !important;}”][vc_row_inner][vc_column_inner animation=”animation bottom-to-top”]\t
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Service Description<\/h3>\n
The metabolome refers to the collection of all small molecule metabolites (< 1500 Da) in cells, tissues, organs or biological organisms, metabolites produced by microorganisms, and all exogenous substances from heterologous organisms.
\nMetabolomics is a research method comprising qualitative and quantitative analysis of all metabolites in an organism. It involves the comparison of the metabolome between control and test groups (for example, a specific gene mutation or environmental change), screening of differential metabolites by statistical analysis, and metabolic pathway analysis of differential metabolites, to identify differences between metabolites and physiological\/pathological changes.
\nUntargeted Metabolomics is an important branch of metabolomics and designed to obtain a metabolite profile and screen for differentially-expressed molecules in the sample. In turn, untargeted medical metabolomics is an important branch of untargeted metabolomics. As many metabolites from different cell samples, microbial samples, animal samples or clinical samples as possible are measured and compared between control and test groups without bias.
\nBGI has extensive experience in the field of untargeted medical metabolomics with well-developed reliable workflows using market leading technologies and a bioinformatics infrastructure that is second to none.<\/div>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row et_full_width=”true” et_row_padding=”true” css=”.vc_custom_1579113590633{padding-top: 60px !important;background-color: #f6f6f6 !important;}”][vc_column][vc_row_inner et_column_align=”align-center” content_placement=”middle”][vc_column_inner width=”1\/2″ animation=”animation bottom-to-top” offset=”vc_col-lg-6″][vc_column_text css=”.vc_custom_1730534632022{margin-bottom: 0px !important;}”]\n

Mass Spectrometry Service Specification<\/h3>\n
Untargeted Metabolomics services are performed using Waters ACQUITY UPLC and cutting-edge mass spectrometer (Q Exactive HF\/HF-X and Q-TOF 5600).<\/div>\n
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Sample Preparation and Services<\/h4>\n
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Increase metabolome depth of coverage using both ACQUITY UPLC BEH C18 and Amide column<\/p>\n

(+) and (-) ESI detection by a Q\u00a0Exactive HF\/HF-X mass spectrometer<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Quality Standard<\/h4>\n
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Summary includes all methods and data analysis<\/p>\n

Reports provided in Excel or PDF format, RAW files available upon request<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Turn Around Time<\/h4>\n
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Typical 5-7 weeks after sample receipt for raw data delivery<\/p>\n<\/div>\n<\/div>\n<\/div>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner width=”1\/2″ animation=”animation bottom-to-top”][vc_column_text css=”.vc_custom_1730534872791{margin-bottom: 0px !important;}”]\n

Research Applications<\/h3>\n

\u2022 Disease biomarkers research
\n\u2022 Pathogenesis and prognosis study on diseases
\n\u2022 Drug compound identification, toxicity assessment and drug efficacy evaluation
\n\u2022 Regulation mechanism of tissue development
\n\u2022 Microbial infection and its pathogenesis
\n\u2022 Animal special behavior mechanism and food\/medicinal value research<\/p>\n

Service Advantages<\/h4>\n\n\n\n\n\n\n
State-of-the-art
\nLC-MS\/MS systems<\/td>\n		Rich large
\nsample experience<\/td>\n		High-precision
\nidentification results<\/td>\n		Strict quality
\ncontrol system<\/td>\n<\/tr>\n
Thermo Q Exactive\u2122 HF-X<\/td>\nHigh throughput automated
\nsample preparation<\/td>\n		Self-built standard library +
\nThermo mzcloud (4000+)<\/td>\n		Strict protocols governing
\nthe whole workflow<\/td>\n<\/tr>\n
Resolution up to 24,000,
\nensuring high spectral
\nquality and accurate results<\/td>\n		Real-time monitoring
\ninstrument detection
\nprocess<\/td>\n		100% identification is
\nachieved through the
\nstandards<\/td>\n		Double quality control
\nprcoess of isotopic internal
\nstandard and QC samples<\/td>\n<\/tr>\n
<\/td>\n<\/td>\nIdentification credibility
\nrating<\/td>\n		<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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